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Multiple sclerosis: One protein, two healing properties.

作者信息

Metcalfe Su M

出版信息

Nature. 2011 Sep 14;477(7364):287-8. doi: 10.1038/477287a.

DOI:10.1038/477287a
PMID:21921909
Abstract
摘要

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Multiple sclerosis: One protein, two healing properties.多发性硬化症：一种蛋白质，两种治愈特性。
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2
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Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development.蛋白激酶CK2决定致脑炎性TH17细胞和调节性T细胞发育之间的分子抉择。
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Neurodegenerative Disease: A Perspective on Cell-Based Therapy in the New Era of Cell-Free Nano-Therapy.

本文引用的文献

1
Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery.靶向纳米颗粒介导细胞因子递送调控 CD4+T 淋巴细胞谱系分化。
Mol Pharm. 2011 Feb 7;8(1):143-52. doi: 10.1021/mp100203a. Epub 2010 Dec 8.
2
Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity.在多发性硬化症的阿仑单抗治疗后，残疾的改善与神经保护性自身免疫有关。
Brain. 2010 Aug;133(Pt 8):2232-47. doi: 10.1093/brain/awq176. Epub 2010 Jul 21.
3
CNS-targeted LIF expression improves therapeutic efficacy and limits autoimmune-mediated demyelination in a model of multiple sclerosis.
神经退行性疾病：细胞游离纳米治疗新时代的细胞治疗视角。
Curr Pharm Des. 2017;23(5):776-783. doi: 10.2174/1381612822666161206141744.
CNS 靶向 LIF 表达可提高多发性硬化症模型的治疗效果并限制自身免疫介导的脱髓鞘。
Mol Ther. 2010 Apr;18(4):684-91. doi: 10.1038/mt.2009.311. Epub 2010 Jan 12.
4
Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6.调节性T细胞与辅助性T细胞17淋巴细胞谱系受白血病抑制因子与白细胞介素-6的交叉调节。
Cell Cycle. 2009 May 1;8(9):1444-50. doi: 10.4161/cc.8.9.8348. Epub 2009 May 4.
5
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.产生白细胞介素17的CD4+效应T细胞通过不同于1型和2型辅助性T细胞谱系的途径发育。
Nat Immunol. 2005 Nov;6(11):1123-32. doi: 10.1038/ni1254. Epub 2005 Oct 2.
6
Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis.注射成年神经球可在多发性硬化症的慢性模型中诱导恢复。
Nature. 2003 Apr 17;422(6933):688-94. doi: 10.1038/nature01552.
7
The unsolved enigmas of leukemia inhibitory factor.白血病抑制因子的未解之谜。
Stem Cells. 2003;21(1):5-14. doi: 10.1634/stemcells.21-1-5.