用树枝状大分子包裹的金纳米颗粒靶向肿瘤微血管。
Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles.
作者信息
Shukla Rameshwer, Hill Elliott, Shi Xiangyang, Kim Jinkoo, Muniz Maria C, Sun Kai, Baker James R
机构信息
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Abor, MI 48109, USA.
出版信息
Soft Matter. 2008;4(11):2160-2163. doi: 10.1039/B810885D.
Abstract
Monodisperse dendrimer-entrapped gold nanoparticles (diameter = 3.0 nm) were prepared using G5 poly(amidoamine) (PAMAM) dendrimer functionalized with fluorescein isothiocyanate (FI) and Arg-Gly-Asp (RGD) peptide as template; in vitro targeting efficacy to integrin receptor expressing cells was confirmed by flow cytometry, confocal microscopy, and ICP-MS.
摘要
使用用异硫氰酸荧光素（FI）和精氨酸-甘氨酸-天冬氨酸（RGD）肽功能化的G5聚（酰胺胺）（PAMAM）树枝状大分子作为模板制备了单分散树枝状大分子包裹的金纳米颗粒（直径 = 3.0 nm）；通过流式细胞术、共聚焦显微镜和电感耦合等离子体质谱法（ICP-MS）证实了其对表达整合素受体细胞具有体外靶向效果。
相似文献
1
Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles.用树枝状大分子包裹的金纳米颗粒靶向肿瘤微血管。
Soft Matter. 2008;4(11):2160-2163. doi: 10.1039/B810885D.
2
Targeting and detecting cancer cells using spontaneously formed multifunctional dendrimer-stabilized gold nanoparticles.利用自发形成的多功能树枝状聚合物稳定的金纳米粒子靶向和检测癌细胞。
Analyst. 2009 Jul;134(7):1373-9. doi: 10.1039/b902199j. Epub 2009 Apr 17.
3
RGD peptide-modified multifunctional dendrimer platform for drug encapsulation and targeted inhibition of cancer cells.RGD 肽修饰的多功能树枝状大分子平台用于药物包封和靶向抑制癌细胞。
Colloids Surf B Biointerfaces. 2015 Jan 1;125:82-9. doi: 10.1016/j.colsurfb.2014.11.004. Epub 2014 Nov 11.
4
Arg-Gly-Asp-D-Phe-Lys peptide-modified PEGylated dendrimer-entrapped gold nanoparticles for targeted computed tomography imaging of breast carcinoma.用于乳腺癌靶向计算机断层扫描成像的精氨酸-甘氨酸-天冬氨酸-D-苯丙氨酸-赖氨酸肽修饰的聚乙二醇化树枝状大分子包裹金纳米颗粒
Nanomedicine (Lond). 2015 Jul;10(14):2185-97. doi: 10.2217/nnm.15.59.
5
Multifunctional dendrimer-entrapped gold nanoparticles modified with RGD peptide for targeted computed tomography/magnetic resonance dual-modal imaging of tumors.多臂树枝状大分子包裹的载 RGD 肽金纳米粒子用于肿瘤的靶向 CT/MR 双模态成像。
Anal Chem. 2015 Apr 7;87(7):3949-56. doi: 10.1021/acs.analchem.5b00135. Epub 2015 Mar 20.
6
Dendrimer-entrapped gold nanoparticles modified with RGD peptide and alpha-tocopheryl succinate enable targeted theranostics of cancer cells.用RGD肽和琥珀酸α-生育酚修饰的树枝状聚合物包裹的金纳米颗粒可实现癌细胞的靶向诊疗。
Colloids Surf B Biointerfaces. 2015 Sep 1;133:36-42. doi: 10.1016/j.colsurfb.2015.05.040. Epub 2015 Jun 3.
7
RGD peptide-modified dendrimer-entrapped gold nanoparticles enable highly efficient and specific gene delivery to stem cells.RGD 肽修饰的树突状聚合物包裹的金纳米粒子能够高效、特异地将基因递送至干细胞。
ACS Appl Mater Interfaces. 2015 Mar 4;7(8):4833-43. doi: 10.1021/am508760w. Epub 2015 Feb 19.
8
Morphological change of gold-dendrimer nanocomposites by laser irradiation.激光辐照下金-树枝状大分子纳米复合材料的形态变化
J Colloid Interface Sci. 2003 Dec 15;268(2):501-6. doi: 10.1016/s0021-9797(03)00598-8.
9
Molecular heterogeneity analysis of poly(amidoamine) dendrimer-based mono- and multifunctional nanodevices by capillary electrophoresis.基于聚（酰胺 - 胺）树枝状大分子的单功能和多功能纳米器件的分子异质性分析：毛细管电泳法
Analyst. 2006 Mar;131(3):374-81. doi: 10.1039/b515624f. Epub 2006 Jan 18.
10
SPECT/CT imaging of chemotherapy-induced tumor apoptosis using Tc-labeled dendrimer-entrapped gold nanoparticles.使用 Tc 标记的树枝状聚合物包裹的金纳米粒子进行 SPECT/CT 成像检测化疗诱导的肿瘤细胞凋亡。
Drug Deliv. 2018 Nov;25(1):1384-1393. doi: 10.1080/10717544.2018.1474968.
引用本文的文献
1
The Peptide Functionalized Inorganic Nanoparticles for Cancer-Related Bioanalytical and Biomedical Applications.肽功能化无机纳米粒子在癌症相关生物分析和生物医学中的应用。
Molecules. 2021 May 27;26(11):3228. doi: 10.3390/molecules26113228.
2
Manganese-Based Targeted Nanoparticles for Postoperative Gastric Cancer Monitoring Magnetic Resonance Imaging.用于术后胃癌监测的磁共振成像的锰基靶向纳米颗粒
Front Oncol. 2020 Oct 19;10:601538. doi: 10.3389/fonc.2020.601538. eCollection 2020.
3
Integrin alpha V beta 3 targeted dendrimer-rapamycin conjugate reduces fibroblast-mediated prostate tumor progression and metastasis.整合素 αVβ3 靶向树枝状聚合物-雷帕霉素偶联物可降低成纤维细胞介导的前列腺肿瘤进展和转移。
J Cell Biochem. 2018 Nov;119(10):8074-8083. doi: 10.1002/jcb.26727. Epub 2018 Jun 22.
4
Dendrimer antibody conjugate to target and image HER-2 overexpressing cancer cells.树枝状聚合物抗体偶联物用于靶向和成像过表达HER-2的癌细胞。
Oncotarget. 2016 Jun 14;7(24):36002-36013. doi: 10.18632/oncotarget.9081.
5
Novel walnut peptide-selenium hybrids with enhanced anticancer synergism: facile synthesis and mechanistic investigation of anticancer activity.具有增强抗癌协同作用的新型核桃肽-硒杂化物：简便合成及抗癌活性机制研究
Int J Nanomedicine. 2016 Apr 11;11:1305-21. doi: 10.2147/IJN.S92257. eCollection 2016.
本文引用的文献
1
Improved biocompatibility of surface functionalized dendrimer-entrapped gold nanoparticles.表面功能化树枝状大分子包裹金纳米颗粒的生物相容性得到改善。
Soft Matter. 2006 Dec 13;3(1):71-74. doi: 10.1039/b612972b.
2
Detection and identification of proteins using nanoparticle-fluorescent polymer 'chemical nose' sensors.使用纳米颗粒-荧光聚合物“化学鼻”传感器检测和鉴定蛋白质。
Nat Nanotechnol. 2007 May;2(5):318-23. doi: 10.1038/nnano.2007.99. Epub 2007 Apr 22.
3
Multi-functional gold nanoparticles for drug delivery.用于药物递送的多功能金纳米颗粒。
Adv Exp Med Biol. 2007;620:48-56. doi: 10.1007/978-0-387-76713-0_4.
4
Label-free antibody-antigen binding detection by optical sensor array based on surface-synthesized gold nanoparticles.基于表面合成金纳米颗粒的光学传感器阵列进行无标记抗体-抗原结合检测。
Biosens Bioelectron. 2008 Mar 14;23(8):1298-302. doi: 10.1016/j.bios.2007.11.023. Epub 2007 Dec 15.
5
Enhanced dispersity of gold nanoparticles modified by omega-carboxyl alkanethiols under the impact of poly(ethylene glycol)s.聚乙二醇作用下ω-羧基链烷硫醇修饰的金纳米颗粒的分散性增强
J Nanosci Nanotechnol. 2007 Sep;7(9):3089-94. doi: 10.1166/jnn.2007.637.
6
Synthetic PAMAM-RGD conjugates target and bind to odontoblast-like MDPC 23 cells and the predentin in tooth organ cultures.合成的聚酰胺-胺-精氨酸-甘氨酸-天冬氨酸共轭物靶向并结合成牙本质细胞样MDPC 23细胞以及牙齿器官培养物中的前期牙本质。
Bioconjug Chem. 2007 Nov-Dec;18(6):1756-62. doi: 10.1021/bc0700234. Epub 2007 Oct 31.
7
Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer.等离子体金纳米颗粒对良性和恶性细胞自发荧光的影响：一种基于荧光的癌症检测新型探针。
Technol Cancer Res Treat. 2007 Oct;6(5):403-12. doi: 10.1177/153303460700600505.
8
Paclitaxel-functionalized gold nanoparticles.紫杉醇功能化金纳米粒子
J Am Chem Soc. 2007 Sep 19;129(37):11653-61. doi: 10.1021/ja075181k. Epub 2007 Aug 24.
9
Functionalized gold nanoparticles for drug delivery.用于药物递送的功能化金纳米颗粒。
Nanomedicine (Lond). 2007 Feb;2(1):113-23. doi: 10.2217/17435889.2.1.113.
10
Locked nucleic acid-nanoparticle conjugates.锁核酸-纳米颗粒缀合物
Chembiochem. 2007 Jul 23;8(11):1230-2. doi: 10.1002/cbic.200700262.
Zotero 插件