Francetic Tanja, Li Qiao
Department of Cellular and Molecular Medicine; Faculty of Medicine; University of Ottawa; Ottawa, ON Canada.
Transcription. 2011 May;2(3):109-114. doi: 10.4161/trns.2.3.15829.
Myogenic regulatory factors (MRFs) are the master regulators of skeletal myogenesis. Among the MRFs, Myf5 is the earliest to be expressed and is regulated by a complex set of enhancers. The expression of Myf5 defines different muscle populations in the somite. Furthermore, Myf5 expression is also found in non-muscle tissues, such as preadipocytes and neurons. Here, we present a current view on the regulation of skeletal myogenesis by transcription factors and cellular signals, with an emphasis on the complexity of transcriptional activation of Myf5. We also discuss Myf5 expression in different populations of myoblasts, preadipocytes and neuronal tissue.
生肌调节因子（MRFs）是骨骼肌生成的主要调节因子。在MRFs中，Myf5是最早表达的，并且受一组复杂的增强子调控。Myf5的表达决定了体节中不同的肌肉群体。此外，在非肌肉组织如前脂肪细胞和神经元中也发现了Myf5的表达。在此，我们阐述了转录因子和细胞信号对骨骼肌生成调控的当前观点，重点关注Myf5转录激活的复杂性。我们还讨论了Myf5在不同群体的成肌细胞、前脂肪细胞和神经组织中的表达。
