染色体表观遗传沉默过程的建模。
Modeling of chromosomal epigenetic silencing processes.
作者信息
Becskei Attila, Scherrer Simone, Kelemen Janos Z, Murray Ann Ehrenhofer
机构信息
Institute of Molecular Life Sciences; University of Zurich; Zurich, Switzerland.
出版信息
Transcription. 2011 Jul;2(4):173-178. doi: 10.4161/trns.2.4.16344.
Abstract
Silenced genes in eukaryotes are packaged into heterochromatin. In addition to establishing a passive storage site for inactive genes in differentiated cells, silencing can play an active role in promoting cellular differentiation. Here, we describe quantitative modeling of silencing processes.
摘要
真核生物中沉默的基因被包装成异染色质。除了在分化细胞中为无活性基因建立一个被动储存位点外，基因沉默还可以在促进细胞分化中发挥积极作用。在这里，我们描述了基因沉默过程的定量模型。
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