Peterson Misty R, Hamdani Omar, Kamakaka Rohinton T
Department of Molecular, Cell and Developmental Biology, University of California - Santa Cruz, 249 Sinsheimer Labs, 1156 High St., Santa Cruz, CA, 95064, USA.
School of Biosciences, University of Kent, Canterbury, UK.
Methods Mol Biol. 2017;1515:151-176. doi: 10.1007/978-1-4939-6545-8_10.
Silenced heterochromatin influences all nuclear processes including chromosome structure, nuclear organization, transcription, replication, and repair. Proteins that mediate silencing affect all of these nuclear processes. Similarly proteins involved in replication, repair, and chromosome structure play a role in the formation and maintenance of silenced heterochromatin. In this chapter we describe a handful of simple tools and methods that can be used to study the atypical role of proteins in gene silencing.
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