谷氨酸脱羧酶65抗体、慢性精神病与2型糖尿病
GAD65 antibodies, chronic psychosis, and type 2 diabetes mellitus.
作者信息
Yarlagadda Atmaram, Taylor Jerome H, Hampe Christiane S, Alfson Elizabeth, Clayton Anita H
机构信息
Department of Psychiatry and Neurobehavioral Sciences, Charlottesville, Virginia, USA.
出版信息
Innov Clin Neurosci. 2011 Aug;8(8):34-6.
Abstract
Glutamic acid decarboxylase is the rate-limiting enzyme in the production of gamma aminobutyric acid, an inhibitory neurotransmitter. Autoantibodies to the glutamic acid decarboxylase 65 isoform have been associated with chronic psychotic disorders and are found in neurons and pancreatic islets. Blood samples were collected from normal controls (n=16), individuals with chronic psychosis with type 2 diabetes mellitus (n=3), and patients with chronic psychosis without diabetes (n=8). No differences were found between any of the groups for frequency of positive glutamic acid decarboxylase 65Ab samples (98th percentile of a healthy control group) or in mean values of glutamic acid decarboxylase 65Ab. Sample size was likely too small to detect differences if they do exist.
摘要
谷氨酸脱羧酶是γ-氨基丁酸（一种抑制性神经递质）生成过程中的限速酶。针对谷氨酸脱羧酶65亚型的自身抗体与慢性精神障碍有关，且在神经元和胰岛中可检测到。采集了正常对照组（n = 16）、患有2型糖尿病的慢性精神病患者（n = 3）以及无糖尿病的慢性精神病患者（n = 8）的血样。在谷氨酸脱羧酶65抗体阳性样本频率（健康对照组的第98百分位数）或谷氨酸脱羧酶65抗体平均值方面，各组之间均未发现差异。如果确实存在差异，样本量可能太小而无法检测到。
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本文引用的文献
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Psychiatry (Edgmont). 2007 Jun;4(6):57-9.
2
Glutamic acid decarboxylase (GAD) antibodies in tardive dyskinesia (TD) as compared to patients with schizophrenia without TD and normal controls.
Schizophr Res. 2008 Oct;105(1-3):287-8. doi: 10.1016/j.schres.2008.06.019. Epub 2008 Aug 16.
3
Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapine.精神分裂症患者血清超氧化物歧化酶和硫代巴比妥酸反应性物质升高：一项关于接受氟哌啶醇或氯氮平治疗患者的研究。
Prog Neuropsychopharmacol Biol Psychiatry. 2006 May;30(3):512-5. doi: 10.1016/j.pnpbp.2005.11.009. Epub 2006 Jan 19.
4
A high prevalence of organ-specific autoimmunity in patients with bipolar disorder.双相情感障碍患者中器官特异性自身免疫的高患病率。
Biol Psychiatry. 2004 Oct 1;56(7):476-82. doi: 10.1016/j.biopsych.2004.07.003.
5
GAD(67): the link between the GABA-deficit hypothesis and the dopaminergic- and glutamatergic theories of psychosis.谷氨酸脱羧酶（67）：γ-氨基丁酸缺乏假说与精神病的多巴胺能和谷氨酸能理论之间的联系。
J Neural Transm (Vienna). 2003 Jul;110(7):803-12. doi: 10.1007/s00702-003-0826-8.
6
Serum S100beta: a noninvasive marker of blood-brain barrier function and brain lesions.血清S100β：血脑屏障功能和脑损伤的非侵入性标志物。
Cancer. 2003 Jun 1;97(11):2806-13. doi: 10.1002/cncr.11409.
7
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8
Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type.S100蛋白的功能作用，EF手型钙结合蛋白。
Biochim Biophys Acta. 1999 Jul 8;1450(3):191-231. doi: 10.1016/s0167-4889(99)00058-0.
9
Species-specific autoantibodies in type 1 diabetes.
J Clin Endocrinol Metab. 1999 Feb;84(2):643-8. doi: 10.1210/jcem.84.2.5503.
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