血脑屏障：谷氨酸脱羧酶抗体在精神病学中的作用
Blood Brain Barrier: The Role of GAD Antibodies in Psychiatry.
作者信息
Yarlagadda Atmaram, Helvink Badalin, Chou Caroline, Clayton Anita H
机构信息
Dr. Yarlagadda is from McDonald Army Health Center, Fort Eustis, Virginia.
出版信息
Psychiatry (Edgmont). 2007 Jun;4(6):57-9.
Abstract
OBJECTIVE
Goal of our case control study was to establish the presence of antibodies to glutamic acid decarboxylase (GAD) in patients with chronic psychotic disorders.
METHODS
Serum levels of GAD antibodies in 12 patients with chronic psychotic disorders (schizophrenia and schizoaffective disorders) and 10 age-matched healthy control subjects were evaluated utilizing enzyme linked immunosorbitent assay (ELISA).
RESULTS
Antibodies to GAD in patients with chronic psychotic disorders have a higher mean than nonpatient control individuals.
CONCLUSION
Our findings provide the first in-vivo evidence of positive GAD antibodies in chronic psychotic disorders and potentially may be used as a screening for these disorders.
摘要
目的
我们这项病例对照研究的目的是确定慢性精神障碍患者中谷氨酸脱羧酶（GAD）抗体的存在情况。
方法
采用酶联免疫吸附测定法（ELISA）评估12例慢性精神障碍患者（精神分裂症和分裂情感性障碍）和10例年龄匹配的健康对照者血清中GAD抗体水平。
结果
慢性精神障碍患者的GAD抗体平均水平高于非患者对照个体。
结论
我们的研究结果首次提供了慢性精神障碍中GAD抗体呈阳性的体内证据，并且有可能用作这些疾病的筛查手段。
相似文献
1
Blood Brain Barrier: The Role of GAD Antibodies in Psychiatry.血脑屏障：谷氨酸脱羧酶抗体在精神病学中的作用
Psychiatry (Edgmont). 2007 Jun;4(6):57-9.
2
The search for an autoimmune origin of psychotic disorders: Prevalence of autoantibodies against hippocampus antigens, glutamic acid decarboxylase and nuclear antigens.寻找精神病性障碍的自身免疫起源：针对海马抗原、谷氨酸脱羧酶和核抗原的自身抗体的流行率。
Schizophr Res. 2021 Feb;228:462-471. doi: 10.1016/j.schres.2020.12.038. Epub 2021 Feb 11.
3
Antibodies to glutamic acid decarboxylase in Syrian and Jordanian type I diabetes patients and their siblings.叙利亚和约旦I型糖尿病患者及其亲属体内谷氨酸脱羧酶抗体
Ann Saudi Med. 2003 Nov-Dec;23(6):376-80. doi: 10.5144/0256-4947.2003.376.
4
Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes.临床前期胰岛素依赖型糖尿病中的谷氨酸脱羧酶自身抗体
Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9841-5. doi: 10.1073/pnas.89.20.9841.
5
Autoantibodies against voltage-gated potassium channel and glutamic acid decarboxylase in psychosis: A systematic review, meta-analysis, and case series.抗电压门控钾通道和谷氨酸脱羧酶自身抗体与精神病：系统评价、荟萃分析和病例系列。
Psychiatry Clin Neurosci. 2017 Oct;71(10):678-689. doi: 10.1111/pcn.12543. Epub 2017 Jul 20.
6
Distribution of autoantibodies to glutamic acid decarboxylase across the spectrum of diabetes mellitus seen in South Africa.南非所见糖尿病谱系中谷氨酸脱羧酶自身抗体的分布情况。
Diabet Med. 2000 Jul;17(7):524-7. doi: 10.1046/j.1464-5491.2000.00324.x.
7
8
Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies.自身免疫性甲状腺疾病患者中谷氨酸脱羧酶自身抗体：与竞争性胰岛素自身抗体的关系。
J Autoimmun. 1995 Oct;8(5):633-43. doi: 10.1006/jaut.1995.0047.
9
10
The ethnic distribution of antibodies to glutamic acid decarboxylase: presence and levels of insulin-dependent diabetes mellitus in Europid and Asian subjects.谷氨酸脱羧酶抗体的种族分布：欧洲人和亚洲受试者中胰岛素依赖型糖尿病的存在情况及水平
J Diabetes Complications. 1993 Jan-Mar;7(1):1-7. doi: 10.1016/1056-8727(93)90016-r.
引用本文的文献
1
Functional and Structural Changes of the Blood-Nerve-Barrier in Diabetic Neuropathy.糖尿病性神经病变中血-神经屏障的功能和结构变化
Front Neurosci. 2019 Jan 14;12:1038. doi: 10.3389/fnins.2018.01038. eCollection 2018.
2
The epidemiologic evidence linking autoimmune diseases and psychosis.将自身免疫性疾病与精神病联系起来的流行病学证据。
Biol Psychiatry. 2014 Feb 15;75(4):300-6. doi: 10.1016/j.biopsych.2013.09.023. Epub 2013 Oct 3.
3
GAD65 antibodies, chronic psychosis, and type 2 diabetes mellitus.谷氨酸脱羧酶65抗体、慢性精神病与2型糖尿病
Innov Clin Neurosci. 2011 Aug;8(8):34-6.
4
Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia.谷氨酸脱羧酶抗体在僵人综合征和小脑性共济失调中的各自意义。
Orphanet J Rare Dis. 2011 Feb 4;6:3. doi: 10.1186/1750-1172-6-3.
5
The blood brain barrier and the role of ratiometric molecular analysis in schizophrenia.血脑屏障与比率分子分析在精神分裂症中的作用。
Psychiatry (Edgmont). 2010 Dec;7(12):20-3.
6
Blood brain barrier: the role of pyridoxine.血脑屏障：维生素B6的作用
Psychiatry (Edgmont). 2007 Aug;4(8):58-60.
本文引用的文献
1
Serum antibodies in epilepsy and seizure-associated disorders.癫痫及癫痫发作相关疾病中的血清抗体。
Neurology. 2005 Dec 13;65(11):1730-6. doi: 10.1212/01.wnl.0000187129.66353.13.
2
Autoantibodies in diabetes.糖尿病中的自身抗体
Diabetes. 2005 Dec;54 Suppl 2:S52-61. doi: 10.2337/diabetes.54.suppl_2.s52.
3
Enterovirus infections with beta-cell tropic strains are frequent in siblings of children diagnosed with type 1 diabetes children and in association with elevated levels of GAD65 antibodies.在被诊断为1型糖尿病儿童的兄弟姐妹中，肠道病毒与β细胞嗜性毒株的感染很常见，且与GAD65抗体水平升高有关。
J Med Virol. 2004 Jul;73(3):450-9. doi: 10.1002/jmv.20111.
4
GABA, gamma-hydroxybutyric acid, and neurological disease.γ-氨基丁酸、γ-羟基丁酸与神经疾病
Ann Neurol. 2003;54 Suppl 6:S3-12. doi: 10.1002/ana.10696.
5
Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia.精神分裂症患者前额叶皮质中一类γ-氨基丁酸（GABA）神经元的基因表达缺陷。
J Neurosci. 2003 Jul 16;23(15):6315-26. doi: 10.1523/JNEUROSCI.23-15-06315.2003.
6
GAD(67): the link between the GABA-deficit hypothesis and the dopaminergic- and glutamatergic theories of psychosis.谷氨酸脱羧酶（67）：γ-氨基丁酸缺乏假说与精神病的多巴胺能和谷氨酸能理论之间的联系。
J Neural Transm (Vienna). 2003 Jul;110(7):803-12. doi: 10.1007/s00702-003-0826-8.
7
Role of calcium regulation in pathophysiology model of schizophrenia and possible interventions.钙调节在精神分裂症病理生理学模型中的作用及可能的干预措施。
Med Hypotheses. 2002 Feb;58(2):182-6. doi: 10.1054/mehy.2001.1511.
8
Acute onset of type I diabetes mellitus after severe echovirus 9 infection: putative pathogenic pathways.严重埃可病毒9感染后I型糖尿病的急性发作：假定的致病途径。
Clin Infect Dis. 2000 Oct;31(4):1025-31. doi: 10.1086/318159. Epub 2000 Oct 25.
9
The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid.僵人综合征：一种影响γ-氨基丁酸神经传递的自身免疫性疾病。
Ann Intern Med. 1999 Oct 5;131(7):522-30. doi: 10.7326/0003-4819-131-7-199910050-00008.
Zotero 插件