Banks William A
Geriatrics Research, Education, and Clinical Center, Puget Sound Health Care System, Seattle, WA, USA.
Methods Mol Biol. 2011;789:337-42. doi: 10.1007/978-1-61779-310-3_22.
Phosphorothioate oligodeoxynucleotides (PODNs) can act as antisense molecules, knocking down proteins. Many PODNs have the unusual characteristic of being transported across the blood-brain barrier by a saturable system. This means that PODNs injected intravenously can accumulate in the central nervous system in quantities sufficient to knock down proteins in brain and the blood-brain barrier. A critical step in the development of PODNs that can be administered peripherally and knockdown proteins in the central nervous system is to determine the relation to the blood-brain barrier, specifically, does the PODN cross the blood-brain barrier and, if so, how fast and to what degree.
硫代磷酸酯寡脱氧核苷酸（PODNs）可作为反义分子，抑制蛋白质表达。许多PODNs具有通过饱和系统穿过血脑屏障的独特特性。这意味着静脉注射的PODNs能够在中枢神经系统中蓄积，并达到足以抑制脑内蛋白质和穿过血脑屏障本身的量。开发可进行外周给药并在中 枢神经系统中抑制蛋白质表达的PODNs的关键步骤是确定其与血脑屏障的关系，具体而言，PODN是否能穿过血脑屏障，如果可以，其速度有多快以及程度如何。
