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Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors.

作者信息

Pollyea Daniel A, Raval Aparna, Kusler Brenda, Gotlib Jason R, Alizadeh Ash A, Mitchell Beverly S

出版信息

Hematol Oncol. 2011 Sep;29(3):157-60. doi: 10.1002/hon.976. Epub 2010 Oct 27.

DOI:10.1002/hon.976
PMID:21922510
Abstract
摘要

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Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors.TET2突变对接受DNA甲基转移酶抑制剂治疗的骨髓增生异常综合征(MDS)患者mRNA表达及临床结局的影响
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2
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Baseline and serial molecular profiling predicts outcomes with hypomethylating agents in myelodysplastic syndromes.基线和连续分子谱分析预测低甲基化剂治疗骨髓增生异常综合征的结果。
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Asian Population Is More Prone to Develop High-Risk Myelodysplastic Syndrome, Concordantly with Their Propensity to Exhibit High-Risk Cytogenetic Aberrations.
亚洲人群更易患高危骨髓增生异常综合征,这与其表现出高危细胞遗传学异常的倾向一致。
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The Impact of DNA Methylation in Hematopoietic Malignancies.DNA甲基化在血液系统恶性肿瘤中的影响
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Digging deep into "dirty" drugs - modulation of the methylation machinery.深入研究“脏”药物——甲基化机制的调控
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The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases.造血和造血疾病中的十十一易位-2(TET2)基因。
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