DNA 损伤及其生物学后果的化学与结构生物学。
Chemistry and structural biology of DNA damage and biological consequences.
机构信息
Department of Chemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37235, USA.
出版信息
Chem Biodivers. 2011 Sep;8(9):1571-615. doi: 10.1002/cbdv.201100033.
Abstract
The formation of adducts by the reaction of chemicals with DNA is a critical step for the initiation of carcinogenesis. The structural analysis of various DNA adducts reveals that conformational and chemical rearrangements and interconversions are a common theme. Conformational changes are modulated both by the nature of adduct and the base sequences neighboring the lesion sites. Equilibria between conformational states may modulate both DNA repair and error-prone replication past these adducts. Likewise, chemical rearrangements of initially formed DNA adducts are also modulated both by the nature of adducts and the base sequences neighboring the lesion sites. In this review, we focus on DNA damage caused by a number of environmental and endogenous agents, and biological consequences.
摘要
化学物质与 DNA 反应形成加合物是引发致癌作用的关键步骤。各种 DNA 加合物的结构分析表明，构象和化学重排及转化是一个共同的主题。构象变化既受加合物的性质又受损伤部位附近碱基序列的调节。构象状态之间的平衡可能调节这些加合物的 DNA 修复和易错复制。同样，最初形成的 DNA 加合物的化学重排也受加合物的性质和损伤部位附近碱基序列的调节。在这篇综述中，我们重点讨论了一些环境和内源性因素引起的 DNA 损伤及其生物学后果。
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