Global R&D, International Specialty Products, Wayne, NJ 07470, USA.
Int J Cosmet Sci. 2012 Feb;34(1):74-80. doi: 10.1111/j.1468-2494.2011.00683.x. Epub 2011 Sep 17.
The stratum corneum (SC) plays a very critical physiological role as skin barrier in regulating water loss through the skin and protects the body from a wide range of physical and chemical exogenous insults. Surfactant-containing formulations can induce skin damage and irritation owing to surfactant absorption and penetration. It is generally accepted that reduction in skin barrier properties occurs only after surfactants have penetrated/permeated into the skin barrier. To mitigate the harshness of surfactant-based cleansing products, penetration/permeation of surfactants should be reduced. Skin impedance measurements have been taken in vitro on porcine skin using vertical Franz diffusion cells to investigate the impact of surfactants, temperature and pH on skin barrier integrity. These skin impedance results demonstrate excellent correlation with other published methods for assessing skin damage and irritation from different surfactant chemistry, concentration, pH, time of exposure and temperature. This study demonstrates that skin impedance can be utilized as a routine approach to screen surfactant-containing formulations for their propensity to compromise the skin barrier and hence likely lead to skin irritation.
角质层 (SC) 在调节皮肤水分流失和保护身体免受广泛的物理和化学外源性伤害方面起着非常关键的生理作用，是皮肤屏障。由于表面活性剂的吸收和渗透，含有表面活性剂的配方会引起皮肤损伤和刺激。人们普遍认为，只有在表面活性剂渗透/渗透到皮肤屏障后，皮肤屏障特性才会降低。为了减轻基于表面活性剂的清洁产品的苛刻性，应减少表面活性剂的渗透/渗透。使用垂直 Franz 扩散池在猪皮上进行了体外皮肤阻抗测量，以研究表面活性剂、温度和 pH 值对皮肤屏障完整性的影响。这些皮肤阻抗结果与其他评估不同表面活性剂化学、浓度、pH 值、暴露时间和温度对皮肤损伤和刺激的已发表方法具有极好的相关性。这项研究表明，皮肤阻抗可以用作常规方法来筛选含有表面活性剂的配方，以评估其破坏皮肤屏障的倾向，从而可能导致皮肤刺激。
