Department of Pharmacology, School of Medicine, Namik Kemal University, Tekirdag, Turkey.
Eur J Pharmacol. 2011 Nov 16;670(1):224-8. doi: 10.1016/j.ejphar.2011.08.039. Epub 2011 Sep 10.
Antidepressants, including selective serotonin reuptake inhibitors (SSRIs), cause erectile dysfunction; however, the mechanism by which they cause erectile function is unclear. We investigated the reactivity of the corpus cavernosum after chronic fluoxetine treatment in rabbits. Twelve rabbits were randomly divided into two groups: control (n=6) or 20mg/kg/day of fluoxetine delivered i.p. (n=6). The reactivity of the corpus cavernosum tissue from the fluoxetine-treated and control groups was studied in organ chambers after 21 days of fluoxetine injection. In the fluoxetine-treated group, endothelium-dependent relaxation of the corpus cavernosum in response to acetylcholine was significantly decreased compared to the control group. However, the sensitivity (i.e., pD(2)) of the fluoxetine-treated cavernosal tissue strips to acetylcholine was not changed with respect to controls. Electrical field stimulation (EFS)-induced neurogenic relaxation was also significantly reduced in the fluoxetine-treated group. Relaxation in response to the nitric oxide (NO) donor sodium nitroprusside was similar between the cavernosal tissues from the two groups. There was also no change in agonist potency between the two groups. Additionally, chronic fluoxetine treatment had no effect on KCl-induced contractile responses. When tissue contraction was produced with phenylephrine to study relaxation in response to various stimuli, the tension induced was similar between the fluoxetine-treated and control groups. This study suggests that chronic fluoxetine treatment causes significant functional changes to the penile erectile tissue of rabbits, and these changes may contribute to the development of impotence.
抗抑郁药，包括选择性 5-羟色胺再摄取抑制剂（SSRIs），会引起勃起功能障碍；然而，它们引起勃起功能的机制尚不清楚。我们研究了慢性氟西汀治疗后兔阴茎海绵体的反应性。12 只兔子随机分为两组：对照组（n=6）或 20mg/kg/天氟西汀腹腔注射（n=6）。氟西汀治疗 21 天后，在器官室中研究了氟西汀治疗组和对照组的阴茎海绵体组织的反应性。与对照组相比，氟西汀治疗组对乙酰胆碱的阴茎海绵体组织的内皮依赖性松弛明显降低。然而，与对照组相比，氟西汀治疗的海绵体组织对乙酰胆碱的敏感性（即 pD2）没有改变。电刺激（EFS）诱导的神经源性松弛在氟西汀治疗组也明显减少。两组海绵体组织对一氧化氮（NO）供体硝普钠的松弛反应相似。两组之间激动剂效力也没有变化。此外，慢性氟西汀治疗对 KCl 引起的收缩反应没有影响。当用苯肾上腺素产生组织收缩以研究对各种刺激的松弛反应时，氟西汀治疗组和对照组之间诱导的张力相似。这项研究表明，慢性氟西汀治疗可导致兔阴茎勃起组织发生显著的功能变化，这些变化可能导致阳痿的发生。
