Psycho-Oncology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa-City, Chiba, Japan.
Jpn J Clin Oncol. 2011 Oct;41(10):1233-7. doi: 10.1093/jjco/hyr119. Epub 2011 Sep 16.
Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D < 5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.
先前的研究报告指出脑源性神经营养因子与重度抑郁症之间存在关联。然而，脑源性神经营养因子在癌症诊断后重度抑郁症的病理生理学中的可能作用尚未得到研究。本研究通过肺癌数据库项目收集了受试者。使用医院焦虑和抑郁量表（HADS-D）的抑郁分量表的截断分数，选择了 81 例抑郁（HADS-D > 10）和 81 例非抑郁（HADS-D < 5）的受试者。两组按年龄、性别、临床分期和表现状态进行匹配。使用酶联免疫吸附测定法测量血清脑源性神经营养因子水平。抑郁组[29.1（13.6）ng/ml；平均值（SD）]和非抑郁组[31.4（10.6）ng/ml]的血清脑源性神经营养因子水平差异无统计学意义（P=0.22）。然而，在按性别分层分析中，在女性（n=24 对）中，抑郁组的平均血清脑源性神经营养因子水平倾向于低于非抑郁组（P=0.06）。癌症诊断后出现的重度抑郁症与血清脑源性神经营养因子水平无关。
