Kurata T, Kurata K, Aoyama Y
Jpn J Exp Med. 1978 Oct;48(5):427-35.
Age-dependent resistance in trigeminal nerve against type 2 herpes simplex virus infection through oral lips and reactivation of the latent virus infection with cyclophosphamide in the ganglion in correlation to theprimary infected part were studied in mice with immunofluorescent and histopathological methods. The mice acquired resistance in the nervous tissue after 8 weeks of age. The viral antigen appeared in all trigeminal ganglia immediately after infection, but not found at 4 weeks later. Reactivation of the latent infection was tried by using 8-week-old mice with cyclophosphamide treatment. Four to five times administration of the drug produced the leasions of herpes simplex virus infection in the ganglia and also in the primary infected areas, but viral antigen-bearing neurons in the ganglia were very few.
通过免疫荧光和组织病理学方法，在小鼠中研究了三叉神经对通过口唇感染的2型单纯疱疹病毒的年龄依赖性抵抗力，以及环磷酰胺对神经节中潜伏病毒感染的激活作用与原发感染部位的相关性。小鼠在8周龄后在神经组织中获得抵抗力。感染后病毒抗原立即出现在所有三叉神经节中，但4周后未发现。通过对8周龄小鼠进行环磷酰胺治疗来尝试激活潜伏感染。四五次给药该药物在神经节以及原发感染区域产生了单纯疱疹病毒感染的病变，但神经节中携带病毒抗原的神经元非常少。
