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胰岛素可诱导克雷布斯II腹水瘤细胞发生细胞黏附并呈现正常的扁平形态。

Insulin induces cell adhesion and normal flattened morphology in Krebs II ascites tumour cells.

作者信息

Pryme I F, Hesketh J E

机构信息

Department of Biochemistry, University of Bergen, Norway.

出版信息

Cell Biol Int Rep. 1990 May;14(5):447-55. doi: 10.1016/0309-1651(90)90095-g.

DOI:10.1016/0309-1651(90)90095-g
PMID:2192802
Abstract

Insulin induced Krebs II ascites cells to attach to the substratum and to adopt a flattened morphology associated with normal adhesion and movement. The changes were associated with a reorganization of cellular actin. The results show that insulin has important effects on cell structure and morphology. Insulin may thus be involved in the nutritional control of normal and malignant growth.

摘要

胰岛素诱导克雷布斯II腹水癌细胞附着于基质，并呈现出与正常黏附和运动相关的扁平形态。这些变化与细胞肌动蛋白的重组有关。结果表明，胰岛素对细胞结构和形态具有重要影响。因此，胰岛素可能参与正常和恶性生长的营养控制。

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引用本文的文献

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Insulin induces changes in the subcellular distribution of actin and 5'-nucleotidase.
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