Cohen O, Mor F, Beigel Y, Prokocimer M, Wysenbeek A J
Internal Medicine B and Hematology Division, Beilinson Medical Center, Petah Tikva, Israel.
Haematologica. 1990 Mar-Apr;75(2):179-81.
A case of hairy cell leukemia and IgG paraproteinemia is described. Peripheral blood surface marker analysis, serum paraprotein levels and immunoperoxidase stains of bone marrow sections at diagnosis and after 7 months of interferon treatment suggested the existence of two unrelated pathological B cell clones: one composed of malignant hairy cells and the other secreting the paraprotein. Previously reported cases of hairy cell leukemia with paraproteins are reviewed and our patient's contribution to the understanding of this association is stressed.
本文描述了一例毛细胞白血病合并IgG副蛋白血症的病例。诊断时及干扰素治疗7个月后的外周血表面标志物分析、血清副蛋白水平及骨髓切片免疫过氧化物酶染色提示存在两个不相关的病理性B细胞克隆：一个由恶性毛细胞组成，另一个分泌副蛋白。对先前报道的毛细胞白血病合并副蛋白的病例进行了综述，并强调了我们的患者对理解这种关联所做的贡献。
