Lum L G
Department of Medicine, Wayne State University, Detroit, Michigan.
Hematol Oncol Clin North Am. 1990 Jun;4(3):659-75.
The donor-derived immune system that forms after bone marrow transplantation (BMT) takes as long as 2 years to develop in healthy BMT recipients. Soon after BMT, GVHD and its treatment increase the susceptibility of the recipient to overwhelming infections, and they retard the development of the immune system. The new system develops from a primitive state characterized by cytotoxic and suppressive functions and progresses to a mature state characterized by the development of specialized lymphocyte functions such as lymphokine production, proliferation, and expression of growth factor receptors. These specialized functions develop in healthy long-term recipients, whereas the same functions may be absent or impaired in those who develop chronic GVHD.
骨髓移植（BMT）后形成的供体来源免疫系统在健康的BMT受者中需要长达2年的时间才能发育成熟。BMT后不久，移植物抗宿主病（GVHD）及其治疗会增加受者对严重感染的易感性，并阻碍免疫系统的发育。新系统从以细胞毒性和抑制功能为特征的原始状态发展而来，逐渐进展到以淋巴因子产生、增殖和生长因子受体表达等专门淋巴细胞功能的发展为特征的成熟状态。这些专门功能在健康的长期受者中得以发展，而在发生慢性GVHD的患者中，这些相同的功能可能会缺失或受损。
