cAMP：分隔信号中的新概念。

cAMP: novel concepts in compartmentalised signalling.

机构信息

Institute of Neuroscience and Molecular Pharmacology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

出版信息

Semin Cell Dev Biol. 2012 Apr;23(2):181-90. doi: 10.1016/j.semcdb.2011.09.005. Epub 2011 Sep 13.

DOI:10.1016/j.semcdb.2011.09.005

PMID:21930230

Abstract

Cyclic adenosine 3,'5'-monophosphate (cAMP) is the archetypal second messenger produced at the membrane by adenylyl cyclase following activation of many different G protein-coupled receptor (GPCR) types. Although discovered over fifty years ago, the notion that cAMP responses were compartmentalised was born in the 1980s. Since then, modern molecular techniques have facilitated visualisation of cellular cAMP dynamics in real time and helped us to understand how a single, ubiquitous second messenger can direct receptor-specific functions in cells. The aim of this review is to highlight emerging ideas in the cAMP field that are currently developing the concept of compartmentalised cAMP signalling systems.

摘要

环磷酸腺苷（cAMP）是一种典型的第二信使，在许多不同的 G 蛋白偶联受体（GPCR）类型被激活后，由膜上的腺苷酸环化酶产生。尽管 cAMP 反应是分隔的概念是在 20 世纪 80 年代才出现的，但这种概念在 50 多年前就已经被发现。从那时起，现代分子技术已经促进了细胞 cAMP 动力学的实时可视化，并帮助我们理解了一种单一的、普遍存在的第二信使如何在细胞中指导受体特异性功能。本综述的目的是强调 cAMP 领域目前正在发展的分隔 cAMP 信号系统的概念。