Ramsewak S S, Kumar A, Welsby R, Mowforth A, Lenton E A, Cooke I D
University of Sheffield, Department of Obstetrics and Gynaecology, Jessop Hospital for Women, UK.
J In Vitro Fert Embryo Transf. 1990 Apr;7(2):103-6. doi: 10.1007/BF01135583.
High oocyte retrieval rates using transvaginal follicular aspiration for single follicles and improved laboratory techniques have engendered renewed interest in natural-cycle in vitro fertilization (IVF). To assess analgesia requirements during single-follicle aspiration, a double-blind study was set up in 30 patients comparing intraprocedure intravenous fentanyl with normal saline as a placebo. Analysis of pain perception using visual analogue scoring showed a similar pain tolerance in both groups for the procedures of vaginal ultrasound scanning, needle insertion, and follicular aspiration. A correlation between each patient's tolerance of common pain-producing experiences with that for the procedure was not well defined (r = 0.5). We conclude that one of the benefits of natural-cycle IVF using transvaginal single-follicle aspiration is that it can be performed without analgesia.
使用经阴道卵泡抽吸术获取单个卵泡的高回收率以及改进的实验室技术，重新引发了人们对自然周期体外受精（IVF）的兴趣。为了评估单卵泡抽吸过程中的镇痛需求，对30例患者进行了一项双盲研究，比较术中静脉注射芬太尼与生理盐水作为安慰剂的效果。使用视觉模拟评分法对疼痛感知进行分析，结果显示两组在阴道超声扫描、针刺插入和卵泡抽吸过程中的疼痛耐受性相似。每位患者对常见疼痛产生经历的耐受性与该手术的耐受性之间的相关性并不明确（r = 0.5）。我们得出结论，使用经阴道单卵泡抽吸术进行自然周期IVF的好处之一是无需镇痛即可进行。
