Zigmond M J, Abercrombie E D, Stricker E M
Department of Behavioral Neuroscience, University of Pittsburgh, PA.
J Neural Transm Suppl. 1990;29:217-32. doi: 10.1007/978-3-7091-9050-0_21.
Parkinson's disease is associated with degeneration of the nigrostriatal bundle. However, the neurological symptoms that accompany this disease do not emerge until the degenerative process is almost complete. Early studies with animals models suggested that the extensive preclinical phase of Parkinsonism was due in part to the development of a compensatory hyperactivity within remaining dopamine-containing neurons. Other studies suggested that systemic administration of L-DOPA could reduce the neurological symptoms once they emerged by further increasing the availability of dopamine in striatum. Subsequent work has supported both hypothesis.
帕金森病与黑质纹状体束的退化有关。然而，这种疾病伴随的神经症状直到退化过程几乎完成时才会出现。早期对动物模型的研究表明，帕金森病广泛的临床前期部分归因于剩余含多巴胺神经元内代偿性活动亢进的发展。其他研究表明，一旦神经症状出现，全身给予左旋多巴可通过进一步增加纹状体中多巴胺的可利用性来减轻这些症状。后续研究支持了这两种假说。
