邓尼特检验法的新视角：填补无作用浓度/最低作用浓度与 ECx 概念之间的空白。
A new perspective on the Dunnett procedure: filling the gap between NOEC/LOEC and ECx concepts.
机构信息
Université de Lyon, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France.
出版信息
Environ Toxicol Chem. 2011 Dec;30(12):2888-91. doi: 10.1002/etc.686. Epub 2011 Oct 14.
DOI:10.1002/etc.686
PMID:21932292
Abstract
The no-observed-effect concentration (NOEC) is known to be based on a wrong usage of hypothesis tests, and the use of confidence intervals is preferred. The purpose of the present study is to provide an easy and proper way to interpret ecotoxicological tests based on simultaneous confidence intervals associated with the commonly used Dunnett procedure, and to show how these intervals may allow one to infer ECx values (effective concentrations).
摘要
无观察效应浓度 (NOEC) 已知是基于假设检验的错误使用，因此更倾向于使用置信区间。本研究的目的是提供一种简单而合适的方法，基于与常用的 Dunnett 程序相关的同时置信区间来解释生态毒理学测试，并展示这些区间如何允许推断 ECx 值（有效浓度）。
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