酸性转录激活结构域与TATA框因子TFIID的直接和选择性结合。
Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID.
作者信息
Stringer K F, Ingles C J, Greenblatt J
机构信息
Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada.
出版信息
Nature. 1990 Jun 28;345(6278):783-6. doi: 10.1038/345783a0.
DOI:10.1038/345783a0
PMID:2193231
Abstract
The potent transactivation domain of the herpes simplex virion protein VP16 was used as a column ligand for affinity chromatography. VP16 binds strongly and highly selectively to the human and yeast TATA box-binding factors. Our results imply that the principal target for acidic activation domains is the TATA-box factor TFIID.
摘要
单纯疱疹病毒粒子蛋白VP16的高效反式激活结构域被用作亲和层析的柱配体。VP16与人及酵母的TATA框结合因子强烈且高度选择性地结合。我们的结果表明，酸性激活结构域的主要靶标是TATA框因子TFIID。
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