腺相关病毒与其辅助病毒之间的相互作用。
The Interplay between Adeno-Associated Virus and its Helper Viruses.
机构信息
Institute of Virology, University of Zurich, CH-8057 Zurich, Switzerland.
出版信息
Viruses. 2020 Jun 19;12(6):662. doi: 10.3390/v12060662.
The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on helper factors to replicate. Those helper factors can be provided by coinfecting helper viruses such as adenoviruses, herpesviruses, or papillomaviruses. We review the basic biology of AAV and its most-studied helper viruses, adenovirus type 5 (AdV5) and herpes simplex virus type 1 (HSV-1). We further outline the direct and indirect interactions of AAV with those and additional helper viruses.
腺相关病毒（AAV）是一种小型、无致病性的细小病毒，需要辅助因子才能复制。这些辅助因子可以通过共感染辅助病毒（如腺病毒、疱疹病毒或乳头瘤病毒）来提供。我们回顾了 AAV 的基本生物学及其研究最多的辅助病毒，即腺病毒 5 型（AdV5）和单纯疱疹病毒 1 型（HSV-1）。我们进一步概述了 AAV 与这些和其他辅助病毒的直接和间接相互作用。
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