Patriarca A, Giacardi M, Mossetti M, Pagliano M
Istituto di Ginecologia ed Ostretricia, Cattedra "A" di Clinica Ostetrica e Ginecologica, Torino.
Minerva Ginecol. 1990 Apr;42(4):103-7.
The scope of this study was to correlate the size and number of growing follicles contemporeaneously in 106 spontaneous cycles and in 126 cycles induced by the administration of clomiphene, gonadotropins and LH-RH microinfusers, in a total of 149 sterile patients with a mean age of 30.2 years. The results have shown that maximum follicular diameter is significantly larger in drug-induced cycles in comparison to spontaneous cycles (p less than 0.05). Nonetheless, ultrasound examination alone is not sufficient to establish follicular development and the time for administering HCG in order to diminish the percentage of hyperstimulation syndromes. Additional biochemical and biological (E2) tests should therefore be performed, as well as a careful study of the endometrial response to induction therapy.
本研究的范围是，在149名平均年龄为30.2岁的不育患者中，关联106个自然周期以及126个通过服用克罗米芬、促性腺激素和促黄体生成素释放激素微注入器诱导的周期中同时生长的卵泡大小和数量。结果表明，与自然周期相比，药物诱导周期中的最大卵泡直径显著更大（p小于0.05）。尽管如此，仅靠超声检查不足以确定卵泡发育情况以及注射人绒毛膜促性腺激素的时间，以便降低过度刺激综合征的发生率。因此，应该进行额外的生化和生物学（雌二醇）检测，以及对子宫内膜对诱导治疗的反应进行仔细研究。
