接受胰岛素治疗的糖尿病儿童的发育和线性生长。

Development and linear growth in diabetic children receiving insulin pigment.

作者信息

Mao Li, Lu Weiping, Ji Feng, Lv Shujun

机构信息

Department of Endocrinology, Huaian No. 1 People's Hospital Affiliated to Nanjing Medical University, Huaian, Jiangsu Province, China.

出版信息

J Pediatr Endocrinol Metab. 2011;24(7-8):433-6. doi: 10.1515/jpem.2011.204.

DOI:10.1515/jpem.2011.204

PMID:21932577

Abstract

OBJECTIVE

The aim of this study was to ascertain if there are differences in the development and linear growth between a group of diabetic children who had been receiving insulin pigment and healthy children.

METHODS

A total of 57 Chinese children with type 1 diabetes diagnosed at the age from 6 to 10 years old (26 boys and 31 girls) were included in the study. Their height and weight and development conditions were recorded until they reached their 18th birthday.

RESULTS

Diabetic children were taller than healthy children at the onset of diabetes, even though there was no significant difference between them [male height standard deviation score (SDS): 0.34 +/- 0.93, female height SDS: 0.38 +/- 0.50]. When they reached their final height, they were slightly shorter than the healthy group. However, there were still no significant differences between these two groups (male height SDS: -0.42 +/- 0.95, female height SDS: -0.60 +/- 0.98). The median age at onset of puberty, 12.62 years in boys and 11.13 years in girls, was significantly delayed in diabetic boys compared to 10.55 years in healthy boys and 9.2 years in healthy girls. The median age at menarche in diabetic girls (14.15 years) was also delayed compared with 12.27 years in healthy girls. The majority of these diabetic children were thinner than the healthy children when they were diagnosed [male body mass index (BMI): 14.45 +/- 1.35 kg/m2 vs. 16.08 +/- 0.59 kg/m2, t = -0.63, p < 0.05; female BMI: 13.50 +/- 1.87 kg/m2 vs. 15.46 +/- 0.45 kg/m2, t = -6.67, p < 0.05]; however, as they reached their final height, they became fatter, especially the girls (male BMI: 21.43 +/- 1.62 kg/m2 vs. 20.8 +/- 0.00 kg/m2, t = 1.97, p > 0.05; female BMI: 23.95 +/- 2.37 kg/m2 vs. 20.3 +/- 0.00 kg/m2, t = 8.60, p < 0.05).

CONCLUSION

Even with well-controlled glucose levels, the development of children with diabetes who had been receiving insulin pigment were still adversely affected. However, linear growth had only been slightly affected. All patients, especially girls, became fatter when they reached their final height.

摘要

目的

本研究旨在确定一组接受胰岛素治疗的糖尿病儿童与健康儿童在发育和线性生长方面是否存在差异。

方法

本研究纳入了57名6至10岁被诊断为1型糖尿病的中国儿童（26名男孩和31名女孩）。记录他们的身高、体重和发育情况，直至年满18岁。

结果

糖尿病儿童在糖尿病发病时比健康儿童高，尽管他们之间没有显著差异[男性身高标准差评分（SDS）：0.34±0.93，女性身高SDS：0.38±0.50]。当他们达到最终身高时，比健康组略矮。然而，这两组之间仍然没有显著差异（男性身高SDS：-0.42±0.95，女性身高SDS：-0.60±0.98）。糖尿病男孩青春期开始的中位年龄为12.62岁，女孩为11.13岁，与健康男孩的10.55岁和健康女孩的9.2岁相比，显著延迟。糖尿病女孩月经初潮的中位年龄（14.15岁）也比健康女孩的12.27岁延迟。这些糖尿病儿童在被诊断时大多比健康儿童瘦[男性体重指数（BMI）：14.45±1.35kg/m²对16.08±0.59kg/m²，t=-0.63，p<0.05；女性BMI：13.50±1.87kg/m²对15.46±0.45kg/m²，t=-6.67，p<0.05]；然而，当他们达到最终身高时，变得更胖，尤其是女孩（男性BMI：21.43±1.62kg/m²对20.8±0.00kg/m²，t=1.97，p>0.05；女性BMI：23.95±2.37kg/m²对20.3±0.00kg/m²，t=8.60，p<0.05）。