Du Caju M V, Rooman R P, op de Beeck L
Department of Pediatrics, University Hospital Antwerp, Belgium.
Pediatr Res. 1995 Oct;38(4):607-11. doi: 10.1203/00006450-199510000-00022.
The available data on growth in children with insulin-dependent diabetes mellitus are conflicting and are mainly derived from cross-sectional studies. In this longitudinal study, height, weight, skeletal age, and pubertal development were recorded until final height was attained in 46 children (22 girls and 24 boys) with onset of diabetes before the age of 10 y. At the onset of diabetes, height SD score (SDS) averaged 0.41 in girls and 0.56 in boys, which was normal when corrected for the secular trend. Prepubertal growth was unaffected in both sexes. Diabetic boys had a marked delay in onset of puberty (mean age at genitalia stage 2: 13.7 y) but attained a normal final height (final height SDS: 0.48 +/- 0.89). In girls final height was slightly reduced (height SDS 0.27 +/- 0.97) due to a suboptimal pubertal growth spurt. Mean pubertal height gain in girls was 16.6 cm and mean age at breast stage 2 was 11.6 y. Diabetic girls also tended to become obese during puberty. Skeletal maturation was normal at all ages. These data suggest that conventional therapy does not guarantee optimal growth, especially in girls.
关于胰岛素依赖型糖尿病患儿生长发育的现有数据相互矛盾，且主要来自横断面研究。在这项纵向研究中，记录了46例10岁前发病的糖尿病患儿（22名女孩和24名男孩）的身高、体重、骨龄和青春期发育情况，直至达到最终身高。糖尿病发病时，女孩的身高标准差评分（SDS）平均为0.41，男孩为0.56，根据长期趋势校正后为正常。青春期前的生长在两性中均未受影响。糖尿病男孩青春期开始明显延迟（生殖器发育2期的平均年龄：13.7岁），但最终身高正常（最终身高SDS：0.48±0.89）。女孩的最终身高略有降低（身高SDS 0.27±0.97），原因是青春期生长突增不理想。女孩青春期平均身高增长为16.6 cm，乳房发育2期的平均年龄为11.6岁。糖尿病女孩在青春期也往往会肥胖。各年龄段的骨骼成熟均正常。这些数据表明，传统治疗不能保证最佳生长，尤其是在女孩中。
