Thein Swee Lay
Department of Molecular Haematology, King's College London, London, UK.
Hemoglobin. 2011;35(5-6):450-62. doi: 10.3109/03630269.2011.613506. Epub 2011 Sep 20.
Professor Titus H.J. Huisman is best known for his work on hemoglobin (Hb) variants. To date, more than 1,000 Hb variants have been discovered and characterized, of which about one-third were discovered in Titus Huisman's laboratory at the Medical College of Georgia, Augusta, GA, USA. A registry of these Hb variants and other information, a legacy from Professor Huisman, is now available online, at HbVar database (hhtp://globin.bx.psu.edu/hbvar). During the last century, major developments in Hb research have been made using physical, chemical, physiological and genetic methods. This review highlights the milestones and key developments in Hb research most relevant to hematologists, and that have impacted our understanding and management of the thalassemias and sickle cell disease.
蒂图斯·H·J·惠斯曼教授因其在血红蛋白（Hb）变体方面的工作而最为知名。迄今为止，已发现并鉴定了1000多种Hb变体，其中约三分之一是在美国佐治亚州奥古斯塔市佐治亚医学院的蒂图斯·惠斯曼实验室中发现的。这些Hb变体的登记信息及其他信息，作为惠斯曼教授留下的遗产，现在可在HbVar数据库（http://globin.bx.psu.edu/hbvar）在线获取。在上个世纪，利用物理、化学、生理和遗传方法在Hb研究方面取得了重大进展。本综述重点介绍了与血液学家最相关的Hb研究中的里程碑和关键进展，这些进展影响了我们对地中海贫血和镰状细胞病的理解与管理。
