Schmand B, Neuvel J, Smolders-de Haas H, Hoeks J, Treffers P E, Koppe J G
Department of Neonatology, Academic Medical Centre, Amsterdam, The Netherlands.
Pediatrics. 1990 Jul;86(1):58-64.
Potential side effects of antenatal administration of corticosteroids to prevent neonatal respiratory distress syndrome were studied in 10- to 12-year-old children whose mothers had participated in a randomized, double-blind, placebo-controlled trial of betamethasone. Aspects of the children's intellectual and motor development, school achievement, and social-emotional functioning were investigated. There were no differences between the corticoid group and the placebo group on these variables, nor were there more children with learning difficulties and behavioral disturbances in either of the groups.
对母亲曾参与倍他米松随机、双盲、安慰剂对照试验的10至12岁儿童，研究了产前使用皮质类固醇预防新生儿呼吸窘迫综合征的潜在副作用。对这些儿童的智力和运动发育、学业成绩以及社会情感功能等方面进行了调查。在这些变量上，皮质类固醇组和安慰剂组之间没有差异，两组中出现学习困难和行为障碍的儿童数量也没有更多。
