Smolders-de Haas H, Neuvel J, Schmand B, Treffers P E, Koppe J G, Hoeks J
Department of Obstetrics, Academic Medical Centre, Amsterdam, The Netherlands.
Pediatrics. 1990 Jul;86(1):65-70.
Potential side effects of antenatal administration of corticosteroids to prevent neonatal respiratory distress syndrome were studied in 10- to 12-year-old children whose mothers had participated in a randomized, double-blind, placebo-controlled trial of betamethasone. The children had a general physical examination; parents were interviewed about the medical history of their child with special attention to infectious diseases; growth data were collected; and a developmental neurological examination, an ophthalmological examination, and a lung function test were conducted. In the corticosteroid group significantly more hospital admissions because of infectious diseases during the first years of life were reported. On the other variables no differences between the corticoid and the placebo groups were found.
对母亲曾参与倍他米松随机、双盲、安慰剂对照试验的10至12岁儿童，研究了产前使用皮质类固醇预防新生儿呼吸窘迫综合征的潜在副作用。对这些儿童进行了全面体检；就其孩子的病史对家长进行了访谈，特别关注传染病；收集了生长数据；并进行了发育神经学检查、眼科检查和肺功能测试。据报告，皮质类固醇组在生命最初几年因传染病住院的人数明显更多。在其他变量方面，未发现皮质类固醇组与安慰剂组之间存在差异。
