与持续高血糖相比，波动的高血糖会增加瘦大鼠的氧化应激反应，尽管其血糖暴露水平较低。
Fluctuating hyperglycaemia increases oxidative stress response in lean rats compared to sustained hyperglycaemia despite lower glycaemic exposure.
机构信息
Section of Biomedicine, Department of Veterinary Disease Biology, University of Copenhagen, Denmark.
出版信息
Diab Vasc Dis Res. 2011 Oct;8(4):295-8. doi: 10.1177/1479164111421033.
OBJECTIVE
To compare the effect of fluctuating glucose with sustained hyperglycaemia on systemic oxidative stress during 72 h of glucose infusion.
METHODS
Catheterised male Sprague-Dawley rats were given either a continuous high (CHG), low (CLG) or pulsatile (FLU) infusion of glucose or saline (VEH) for 72 h. Plasma ascorbate oxidation ratio (AOR) and malondialdehyde (MDA) were used as biomarkers of oxidative stress and damage.
RESULTS
The FLU group showed significant increases in both plasma AOR and MDA at 48 and 72 h (p < 0.05 all cases), whereas the CHG group, despite being infused with three times the amount of glucose, only showed increased MDA levels at 72 h time point (p < 0.05).
CONCLUSION
Our data suggests that fluctuating glucose levels lead to oxidative stress similar to that of sustained hyperglycaemia despite a much lower total glycaemic exposure. Thus, our data supports the notion that fluctuating glucose may be relatively more deleterious than sustained hyperglycaemia.
目的
比较波动血糖与持续高血糖对葡萄糖输注 72 小时期间全身氧化应激的影响。
方法
将雄性 Sprague-Dawley 大鼠置管后分别给予持续高（CHG）、低（CLG）或波动（FLU）葡萄糖输注或生理盐水（VEH）输注 72 小时。血浆抗坏血酸氧化比（AOR）和丙二醛（MDA）用作氧化应激和损伤的生物标志物。
结果
FLU 组在 48 和 72 小时时血浆 AOR 和 MDA 均显著升高（所有情况均 p<0.05），而 CHG 组尽管输注了三倍量的葡萄糖，仅在 72 小时时 MDA 水平升高（p<0.05）。
结论
我们的数据表明，波动的血糖水平会导致与持续高血糖相似的氧化应激，尽管总血糖暴露量要低得多。因此，我们的数据支持波动的血糖可能比持续高血糖更具危害性的观点。
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