Department of Surgery, University of Heidelberg, Heidelberg, Germany.
Pancreas. 2012 Mar;41(2):212-7. doi: 10.1097/MPA.0b013e3182240602.
To investigate the incidence, characteristics, and prognostic impact of prior extrapancreatic malignancies on patients with pancreatic cancer (PDAC).
Records from 1733 patients who underwent surgery for PDAC were analyzed for the occurrence of prior extrapancreatic malignancies. Patients' records showing extrapancreatic malignancies were then analyzed for tumor type, epidemiological data, risk factors, PDAC tumor stage, and long-term survival.
A total of 239 patients with PDAC (13.8%) had a history of 271 extrapancreatic tumors; 26 patients had a history of two pancreatic cancers, and 3 patients had 3 extrapancreatic cancers. The most common extrapancreatic tumors were breast cancer (56 patients) and prostate cancer (41 patients), followed by colorectal, reno/urothelial, and gynecologic tumors (39, 32, and 23 patients, respectively). No significant difference in overall survival was found between patients with PDAC with or without extrapancreatic malignancies.
Pancreatic cancer is associated with extrapancreatic malignancies in a remarkable number of patients. A history of extrapancreatic malignancies does not influence prognosis and should not be an obstacle to a curative therapeutic approach. Surveillance of patients with extrapancreatic malignancies, especially breast, prostate, and colorectal cancer, could allow for earlier PDAC diagnosis and therefore improve prognosis of these patients.
研究既往胰外恶性肿瘤对胰腺癌（PDAC）患者的发病率、特征和预后影响。
对 1733 例接受 PDAC 手术的患者的记录进行分析，以了解胰外恶性肿瘤的发生情况。然后对显示胰外恶性肿瘤的患者记录进行肿瘤类型、流行病学数据、危险因素、PDAC 肿瘤分期和长期生存情况的分析。
共有 239 例 PDAC 患者（13.8%）有 271 例胰外肿瘤病史；26 例患者有两次胰腺癌病史，3 例患者有 3 例胰外肿瘤病史。最常见的胰外肿瘤是乳腺癌（56 例）和前列腺癌（41 例），其次是结直肠、肾/尿路上皮和妇科肿瘤（分别为 39、32 和 23 例）。有无胰外恶性肿瘤的 PDAC 患者的总体生存率无显著差异。
胰腺癌与相当数量的胰外恶性肿瘤有关。胰外恶性肿瘤病史并不影响预后，不应成为根治性治疗方法的障碍。对胰外恶性肿瘤患者，特别是乳腺癌、前列腺癌和结直肠癌患者进行监测，可以更早地诊断 PDAC，从而改善这些患者的预后。
