Jones Virginia M
Department of Pharmacy Services, University Health Care, and College of Pharmacy, University of Utah, Salt Lake City, Utah 84108, USA.
J Pain Palliat Care Pharmacother. 2011;25(4):340-9. doi: 10.3109/15360288.2011.606293. Epub 2011 Sep 21.
Acetaminophen injection is an antipyretic and analgesic agent recently marketed in the United States as Ofirmev. Five published trials directly compare acetaminophen injection to drugs available in the United States. For management of pain in adults, acetaminophen injection was at least as effective as morphine injection in renal colic, oral ibuprofen after cesarean delivery, and oral acetaminophen after coronary artery bypass surgery. In children (3 to 16 years old), single-dose acetaminophen injection was similar to meperidine intramuscular (i.m.) for pain after tonsillectomy; readiness for discharge from the recovery room was shorter with acetaminophen injection (median 15 minutes) compared with meperidine i.m. (median 25 minutes), P = .005. In children (2 to 5 years old) postoperative adenotonsillectomy or adenoidectomy, the time to rescue analgesia was superior with high-dose acetaminophen rectal suppository (median 10 hours) compared with acetaminophen injection (median 7 hours), P = .01. One published trial demonstrated acetaminophen injection is noninferior to propacetamol injection for fever related to infection in pediatric patients. Dosing adjustments are not required when switching between oral and injectable acetaminophen formulations in adult and adolescent patients. Acetaminophen injection represents another agent for multimodal pain management.
对乙酰氨基酚注射液是一种解热镇痛药，最近在美国作为奥菲默（Ofirmev）上市。五项已发表的试验直接将对乙酰氨基酚注射液与美国现有的药物进行了比较。在成人疼痛管理方面，对乙酰氨基酚注射液在肾绞痛、剖宫产术后口服布洛芬以及冠状动脉搭桥手术后口服对乙酰氨基酚的治疗中，疗效至少与吗啡注射液相当。在儿童（3至16岁）中，单剂量对乙酰氨基酚注射液与扁桃体切除术后疼痛的哌替啶肌内注射效果相似；与哌替啶肌内注射（中位数25分钟）相比，对乙酰氨基酚注射液（中位数15分钟）使患儿从恢复室出院的准备时间更短，P = 0.005。在儿童（2至5岁）行腺样体扁桃体切除术或腺样体切除术后，与对乙酰氨基酚注射液（中位数7小时）相比，高剂量对乙酰氨基酚直肠栓剂的补救镇痛时间更短（中位数10小时），P = 0.01。一项已发表的试验表明，在儿科患者中，对乙酰氨基酚注射液在治疗感染相关发热方面不劣于丙帕他莫注射液。在成人和青少年患者中，在口服和注射用对乙酰氨基酚制剂之间切换时无需调整剂量。对乙酰氨基酚注射液是多模式疼痛管理的另一种药物。
