Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada.
World J Biol Psychiatry. 2012 Mar;13(3):232-8. doi: 10.3109/15622975.2011.598560. Epub 2011 Sep 22.
Alcohol use disorders (AUD) act as a risk factor for smoking relapse, and tobacco dependent (TD) subjects with comorbid AUD experience more withdrawal symptoms compared to TD subjects without AUD or other psychiatric comorbidities. Our aim was to investigate whether drinking behaviour in the past 12 months and smoking relapse due to alcohol use in TD subjects was associated with polymorphisms flanking the TTC12/ANKK1/DRD2 region since associations have been found between these genes and AUD and TD as separate disorders.
380 TD subjects were assessed for alcohol use and relapse to smoking. Subjects were genotyped for polymorphisms located in the TTC12/ANKK1/DRD2 region.
Associations were found between ANKK1 haplotype rs4938015C_rs11604671A and age of onset of daily smoking, as well as with hazardous drinking. No genetic association was found with smoking relapse due to alcohol consumption.
Our findings suggest that TD subjects who present earlier age at onset and carry this haplotype may have a higher risk for developing an alcohol use disorder.
酒精使用障碍（AUD）是吸烟复发的危险因素，与无 AUD 或其他精神共病的烟草依赖（TD）受试者相比，同时患有 AUD 的 TD 受试者经历更多的戒断症状。我们的目的是研究过去 12 个月的饮酒行为以及 TD 受试者因酒精使用而导致的吸烟复发是否与 TTC12/ANKK1/DRD2 区域侧翼的多态性有关，因为这些基因与 AUD 和 TD 作为单独的疾病之间存在关联。
对 380 名 TD 受试者进行酒精使用和吸烟复发评估。对位于 TTC12/ANKK1/DRD2 区域的多态性进行基因分型。
ANKK1 单倍型 rs4938015C_rs11604671A 与每日吸烟的发病年龄以及危险饮酒有关。与因饮酒导致的吸烟复发无遗传关联。
我们的研究结果表明，出现更早发病年龄且携带该单倍型的 TD 受试者可能有更高的酒精使用障碍风险。
