Corbeil L B
Department of Pathology, UCSD Medical Center 92103.
Can J Vet Res. 1990 Apr;54 Suppl:S57-62.
Several virulence factors of Haemophilus somnus have been investigated, but to a varying extent. It is known that some isolates are more virulent than others. Factors associated with virulence include attachment to vaginal epithelial cells, turbinate cells or embryos; serum resistance; growth stimulation by normal flora; interference with phagocyte function; Fc receptors; and toxicity for several bovine cell types. Lipooligosaccharide and Fc receptors have been investigated at the molecular level and studies are in progress to relate their molecular structure to virulence.
已经对睡眠嗜血杆菌的几种毒力因子进行了研究，但程度各异。已知一些分离株比其他分离株的毒力更强。与毒力相关的因素包括对阴道上皮细胞、鼻甲细胞或胚胎的附着；血清抗性；正常菌群对生长的刺激；对吞噬细胞功能的干扰；Fc受体；以及对几种牛细胞类型的毒性。脂寡糖和Fc受体已在分子水平上进行了研究，并且正在开展研究以将它们的分子结构与毒力联系起来。
