1st Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University Munich, Germany.
Histol Histopathol. 2011 Nov;26(11):1415-22. doi: 10.14670/HH-26.1415.
Inhibins, dimeric peptide hormones composed of an alpha-subunit and one of two possible beta-subunits (betaA or betaB), exhibit substantial roles in human reproduction and in endocrine-responsive tumours. However, the prognostic significance and clinical implications of the inhibin-betaB subunit in uterine endometrioid adenocarcinomas is still not defined yet. A series of 227 uterine endometrioid adenocarcinomas of a previous well-characterized cohort were re-evaluated for the expression of the inhibin-betaB subunit and correlated with several clinicopathological characteristics and the clinical outcome. In this re-analysis, the betaB-subunit expression demonstrated a significant association with the patients' age and cervical involvement. However, inhibin-betaB did not significantly affect the patients survival in this large cohort group. However, patients with a higher intensity of betaB-subunit immunolabelling had a slightly worse survival expectation, although without any significant association, suggesting that this subunit might have a substantial role in the carcinogenesis and pathology of endometrioid adenocarcinomas. Thus, the inhibin-betaB subunit appears not to be a useful prognostic marker regarding endometrioid adenocarcinomas. However, further research is warranted in elucidating the possible implications of inhibin-βB and endometrial carcinogenesis.
抑制素是由一个α亚基和两个β亚基（βA 或βB）之一组成的二聚肽激素，在人类生殖和内分泌反应性肿瘤中发挥重要作用。然而，抑制素-βB 亚基在子宫内膜样腺癌中的预后意义和临床意义尚不清楚。本研究重新评估了之前经过充分特征描述的 227 例子宫内膜样腺癌中抑制素-βB 亚基的表达，并将其与多种临床病理特征和临床结局相关联。在这项重新分析中，βB 亚基的表达与患者的年龄和宫颈受累显著相关。然而，在这个大的队列组中，抑制素-βB 并没有显著影响患者的生存。然而，βB 亚基免疫标记强度较高的患者的生存预期略差，尽管没有显著相关性，但这表明该亚基可能在子宫内膜样腺癌的发生和病理中发挥重要作用。因此，抑制素-βB 亚基似乎不是子宫内膜样腺癌的一个有用的预后标志物。然而，需要进一步研究来阐明抑制素-βB 和子宫内膜癌发生之间的可能影响。
