Dpto. Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Universidad de Córdoba, Spain.
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Dec 1;35(8):1944-9. doi: 10.1016/j.pnpbp.2011.09.005. Epub 2011 Sep 12.
This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue.
Rats were given 3-NP over four consecutive days (20 mg/kg BW), while melatonin was administered over 21 days (1 mg/kg/BW), starting after the last injection of 3-NP.
Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage.
Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action.
本研究旨在确定褪黑素是否会引起神经营养因子的变化，并在脑组织中对霉菌毒素 3-硝基丙酸（3-NP）起到保护作用。
大鼠连续四天接受 3-NP（20mg/kgBW）处理，而褪黑素则在最后一次注射 3-NP 后开始的 21 天内（1mg/kg/BW）给药。
接受 3-NP 处理的大鼠的神经营养因子（BDNF 和 GDNF）水平发生显著变化，同时行为也发生了改变；它们还表现出广泛的氧化应激和大量神经元损伤。
褪黑素改善了 3-NP 处理大鼠的行为改变，减少了氧化损伤，降低了神经营养因子水平和神经元丢失。这些结果表明褪黑素具有神经保护作用。
