Department of Biological Sciences, University of Alberta, Edmonton, Canada.
Water Res. 2011 Nov 15;45(18):5849-57. doi: 10.1016/j.watres.2011.08.032. Epub 2011 Sep 7.
We evaluated whether ozonation ameliorated the effects of the organic fraction of oil sands process water (OSPW) on immune functions of mice. Ozonation of OSPW eliminated the capacity of its organic fraction to affect various mouse bone marrow-derived macrophage (BMDM) functions in vitro. These included the production of nitric oxide and the expression of inducible nitric oxide synthase, the production of reactive oxygen intermediates and the expression of NADPH oxidase subunits, phagocytosis, and the expression of pro-inflammatory cytokine genes. Ozone treatment also eliminated the ability of OSPW organic fraction to down-regulate the expression of various pro-inflammatory cytokine and chemokine genes in the liver of mice, one week after oral exposure. We conclude that ozone treatment may be a valuable process for the remediation of large volumes of OSPW.
我们评估了臭氧化是否能改善油砂开采废水（OSPW）有机部分对小鼠免疫功能的影响。臭氧化 OSPW 消除了其有机部分影响各种体外小鼠骨髓来源的巨噬细胞（BMDM）功能的能力。这些功能包括一氧化氮的产生和诱导型一氧化氮合酶的表达、活性氧中间体的产生和 NADPH 氧化酶亚基的表达、吞噬作用以及促炎细胞因子基因的表达。臭氧处理还消除了 OSPW 有机部分在口服暴露一周后下调小鼠肝脏中各种促炎细胞因子和趋化因子基因表达的能力。我们得出结论，臭氧处理可能是修复大量 OSPW 的有价值的工艺。
