Huang Dexiao, Chen Yong, Zeng Qingle, Zhao Jianbo, Wu Renhua, Wu Xizhong, Li Yanhao
Department of Medical Imaging, Medical College of Shnatou University, Shantou, China.
Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1736-41. doi: 10.5754/hge11174. Epub 2011 Jul 15.
BACKGROUND/AIMS: Surgical resection is the current treatment for focal nodular hyperplasia of the liver (FNH) when indicated. However, tumor location and size, patient comorbidities, and risk of complications may limit surgical options in some cases. Our goal was to evaluate the therapeutic effect of transarterial embolization (TAE) using pingyangmycin lipiodol emulsion (PLE) and polyvinyl alcohol particles to treat FNH.
Four patients with FNH, who experienced dull pain in the upper abdomen or liver area and confirmed by biopsy, were treated by TAE with PLE and polyvinyl alcohol (diameter: 500µm-700µm). Therapeutic effects including changes in lesion diameter and symptomatic improvement, and occurrence of complications, were evaluated for a follow-up period ranging from 12 to 42 months after the procedure.
All of four patients were successfully treated with PLE and polyvinyl alcohol embolization. One month after the procedure, dull pain in the upper abdomen or liver area vanished completely. Follow-up examination by CT or MRI revealed complete resolution in two cases and an obvious decrease in the other two cases. No immediate or delayed postembolization complications were encountered.
Transarterial embolization using PLE and polyvinyl alcohol should be considered as a safe and effective method for the treatment of FNH.
背景/目的：手术切除是目前肝局灶性结节性增生（FNH）有指征时的治疗方法。然而，肿瘤位置和大小、患者合并症以及并发症风险在某些情况下可能会限制手术选择。我们的目标是评估使用平阳霉素碘油乳剂（PLE）和聚乙烯醇颗粒进行经动脉栓塞（TAE）治疗FNH的疗效。
4例经活检确诊为FNH且有上腹部或肝区隐痛的患者，采用含PLE和聚乙烯醇（直径：500µm - 700µm）的TAE进行治疗。在术后12至42个月的随访期内，评估包括病变直径变化、症状改善情况以及并发症发生情况在内的治疗效果。
4例患者均成功接受PLE和聚乙烯醇栓塞治疗。术后1个月，上腹部或肝区隐痛完全消失。CT或MRI随访检查显示，2例病变完全消退，另外2例明显缩小。未出现栓塞后即刻或延迟并发症。
使用PLE和聚乙烯醇进行经动脉栓塞应被视为治疗FNH的一种安全有效的方法。
