Furutani M, Ito K, Oku Y, Takeda Y, Igarashi K
Faculty of Pharmaceutical Sciences, Chiba University.
Microbiol Immunol. 1990;34(4):387-92. doi: 10.1111/j.1348-0421.1990.tb01019.x.
A new Vero toxin purified from Escherichia coli O91:H21 isolated from a patient with the hemolytic uremic syndrome (VT2vh) was shown to inhibit elongation factor 1-dependent aminoacyl-tRNA binding to ribosomes, resulting in inhibition of protein synthesis in rabbit reticulocytes. VT2vh, like Shiga toxin, VT1 and VT2, showed RNA N-glycosidase activity and cleaved the N-glycosidic bond of the adenosine residue at position 4324 in 28S ribosomal RNA.
从一名溶血尿毒综合征患者分离出的大肠杆菌O91:H21中纯化出的一种新型维罗毒素（VT2vh），被证明可抑制延伸因子1依赖性氨酰基-tRNA与核糖体的结合，从而抑制兔网织红细胞中的蛋白质合成。VT2vh与志贺毒素、VT1和VT2一样，具有RNA N-糖苷酶活性，并切割28S核糖体RNA中第4324位腺苷残基的N-糖苷键。
