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一例患有晚期且高Gleason评分前列腺癌的脊髓延髓肌肉萎缩症患者对最大雄激素阻断疗法有反应。

A case of spinal and bulbar muscular atrophy with high-stage and high-Gleason Score prostate cancer responded to maximal androgen blockade therapy.

作者信息

Kosaka Takeo, Miyajima Akira, Kikuchi Eiji, Takahashi Shinichi, Suzuki Norihiro, Oya Mototsugu

机构信息

Keio University School of Medicine, Department of Urology, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

出版信息

J Androl. 2012 Jul-Aug;33(4):563-5. doi: 10.2164/jandrol.111.013698. Epub 2011 Sep 22.

DOI:10.2164/jandrol.111.013698
PMID:21940987
Abstract

Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by the expansion of CAG triplets in the androgen receptor. Because the length of CAG repeat is inversely related with androgen receptor function, patients with a longer CAG repeat are expected to have a lower incidence of prostate cancer. Here, we report an extremely rare case of high-stage prostate cancer in a patient with spinal and bulbar muscular atrophy, which responded to maximal androgen blockade therapy.

摘要

脊髓延髓肌肉萎缩症是一种由雄激素受体中CAG三联体扩增引起的遗传性运动神经元疾病。由于CAG重复序列的长度与雄激素受体功能呈负相关，预计CAG重复序列较长的患者患前列腺癌的几率较低。在此，我们报告了一例极为罕见的脊髓延髓肌肉萎缩症患者发生晚期前列腺癌的病例，该病例对最大雄激素阻断疗法有反应。

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