PRC2 复合物的组成、募集和调控。
Composition, recruitment and regulation of the PRC2 complex.
机构信息
Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, Ontario, Canada.
出版信息
Nucleus. 2011 Jul-Aug;2(4):277-82. doi: 10.4161/nucl.2.4.16266. Epub 2011 Jul 1.
The PRC2 histone methyltransferase complex is an important regulator of gene expression programs in metazoans. Gene expression regulation by the PRC2 complex is critical for development and cell differentiation. Several recent studies have begun to shed light on the molecular basis for the physiological function of the PRC2 complex. Here, we discuss some of these results and how they provide new insights into the composition, recruitment and regulation of the PRC2 complex.
PRC2 组蛋白甲基转移酶复合物是后生动物基因表达程序的重要调控因子。PRC2 复合物对基因表达的调控对于发育和细胞分化至关重要。最近的几项研究开始揭示 PRC2 复合物生理功能的分子基础。在这里，我们讨论其中的一些结果，以及它们如何为 PRC2 复合物的组成、募集和调控提供新的见解。
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