Fernandez Conrad V, Li Ning, Mullen Elizabeth A, Grundy Paul E, Perman Elizabeth J, Shamberger Robert C, Ehrlich Peter F, Dome Jeffrey S
Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia.
J Pediatr Hematol Oncol. 2011 Oct;33(7):521-3. doi: 10.1097/MPH.0b013e31821b8dd5.
Very low risk Wilms tumor is defined by favorable histology, age below 2 years, tumor weight less than 550 g, and stage I. The Children's Oncology Group is currently studying a nephrectomy-only strategy for these patients but the accrual rate is slightly below expected. Twenty-five of 31 institutions responded with reasons by physicians and/or parents for electing not to participate. Parents were primarily concerned with the experimental nature of the study, whereas physicians were concerned about accurate staging, with some overlap. We point out the necessity of assessing these concerns in predicting feasibility of and accrual to a therapy reduction study.
极低风险的肾母细胞瘤由组织学良好、年龄小于2岁、肿瘤重量小于550克以及I期来定义。儿童肿瘤协作组目前正在研究针对这些患者仅行肾切除术的策略，但入组率略低于预期。31家机构中有25家回复了医生和/或家长选择不参与的原因。家长主要担心研究的试验性质，而医生则担心准确分期，存在一些重叠。我们指出在预测治疗方案简化研究的可行性和入组率时评估这些担忧的必要性。
