Urban C E, Lackner H, Schwinger W, Klos I, Höllwarth M, Sauer H, Ring E, Gadner H, Zoubek A
Division of Hematology/Oncology, University Children's Hospital, Graz, Austria.
Pediatr Hematol Oncol. 1995 Mar-Apr;12(2):143-52. doi: 10.3109/08880019509029547.
We report on 3 of 21 stage I Wilms' tumor patients with tumor volumes of 190, 890, and 1300 mL, respectively, who responded dramatically to preoperative chemotherapy according to the Austrian/Hungarian Wilms' Tumor Study 89 by tumor volume reductions to 20%, 23%, and 13%, respectively. Radical resection of the tumors with renal preservation was achieved in all patients. Postoperative studies did not show any functional deficit in the preserved kidney. The patients have been in complete remission for 26, 33, and 60 months, respectively. Our preliminary results indicate that tumor resection should be feasible in patients with good responding stage I Wilms' tumors.
我们报告了21例I期威尔姆斯瘤患者中的3例，其肿瘤体积分别为190、890和1300 mL。根据奥地利/匈牙利威尔姆斯瘤研究89，这3例患者对术前化疗反应显著，肿瘤体积分别缩小至20%、23%和13%。所有患者均成功进行了保留肾脏的肿瘤根治性切除术。术后研究未显示保留肾脏有任何功能缺陷。这些患者分别已完全缓解26、33和60个月。我们的初步结果表明，对于I期威尔姆斯瘤反应良好的患者，肿瘤切除应该是可行的。
