Martinez-Duncker Ivan, Salinas-Marin Roberta, Martinez-Duncker Carlos
Human Glycobiology Laboratory, Science Faculty, Autonomous University of the State of Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, MOR, Mexico.
Int J Mol Imaging. 2011;2011:283497. doi: 10.1155/2011/283497. Epub 2011 Sep 19.
In vivo assessment of tumor glucose catabolism by positron emission tomography (PET) has become a highly valued study in the medical management of cancer. Emerging technologies offer the potential to evaluate in vivo another aspect of cancer carbohydrate metabolism related to the increased anabolic use of monosaccharides like sialic acid (Sia). Sia is used for the synthesis of sialylated oligosaccharides in the cell surface that in cancer cells are overexpressed and positively associated to malignancy and worse prognosis because of their role in invasion and metastasis. This paper addresses the key points of the different strategies that have been developed to image Sia expression in vivo and the perspectives to translate it from the bench to the bedside where it would offer the clinician highly valued complementary information on cancer carbohydrate metabolism that is currently unavailable in vivo.
通过正电子发射断层扫描（PET）对肿瘤葡萄糖分解代谢进行体内评估已成为癌症医学管理中一项备受重视的研究。新兴技术有望在体内评估癌症碳水化合物代谢的另一个方面，这与诸如唾液酸（Sia）等单糖合成代谢的增加有关。Sia用于细胞表面唾液酸化寡糖的合成，在癌细胞中这些寡糖过度表达，并且由于它们在侵袭和转移中的作用而与恶性肿瘤和较差的预后呈正相关。本文阐述了已开发出的用于体内成像Sia表达的不同策略的关键点，以及将其从实验室转化到临床应用的前景，在临床应用中它将为临床医生提供目前体内无法获得的关于癌症碳水化合物代谢的高度有价值的补充信息。
