Wakai Satoyo, Yajima Mikihisa
Division of Research and Examination, National Hospital Organization Nishisaitama-Chuo National Hospital, Saitama, Japan.
Nihon Hansenbyo Gakkai Zasshi. 2011 Sep;80(3):269-74. doi: 10.5025/hansen.80.269.
We report the results of an examination of gross images of two patients with Buruli ulcer and a histopathological evaluation of surgically removed skin from two other cases at the non-ulcerated and ulcerated stages, respectively. Histopathologically, dermal nodes were found in the non-ulcerated specimen; while wide necrosis of skin and fibrin deposition, as well as Langhans giant cell, epitheloid cells, and vasculitis, were observed in the ulcerated specimen, with granuloma in the lymph nodes. M. ulcerans was positive in a Fite stain and in a PGL-1 immunohistological stain. Based on these cases, we discuss the histological characteristics of Buruli ulcer.
我们报告了对两名布鲁里溃疡患者的大体图像检查结果，以及另外两例分别处于非溃疡期和溃疡期的手术切除皮肤的组织病理学评估结果。组织病理学上，在非溃疡标本中发现了真皮结节；而在溃疡标本中观察到皮肤广泛坏死、纤维蛋白沉积，以及朗汉斯巨细胞、上皮样细胞和血管炎，淋巴结中有肉芽肿。溃疡分枝杆菌在抗酸染色和PGL-1免疫组织化学染色中呈阳性。基于这些病例，我们讨论了布鲁里溃疡的组织学特征。
