Wang Jiandong, Wu Minghui, Zhang Songwen, Li Changdong, Zhang Weiyuan
Department of Gynaecology Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Eur J Gynaecol Oncol. 2011;32(4):411-4.
To determine the prevalence and factors associated with histologic diagnoses of cervical intraepithelial neoplasia in women with ASC-US.
Sampling investigations were carried out on married women aged 25-54 in 12 districts in Beijing from April 2007 to November 2008. Further examinations and analyses were carried out on women with ASC-US in the cytological screening.
Of 6,339 women, 9.6% suffered from cervical abnormalities in cytology; among them, 409 cases were ASC-US. Of the 409 ASC-US, 42.1% showed inflammation; 50.9% had CIN 1, 6.1% had CIN 2, and three cases had CIN 3, one of which was cervical cancer. Four hundred and four cases were subjected to detection for the human papillomaovirus (HPV) and the infection rate was 30.7%. Morbidity in the HPV infected patients that suffered from CIN 2 or higher was significantly higher than that in the uninfected population (chi2 = 26.685, p = 0.000). No statistical significance was found in the correlation between the pathological results of ASC-US and the loading dose of HPV infection (chi2 = 7.754, p = 0.458).
The morbidity of CIN in women with ASCUS in Beijing is high, and women with ASC-US should be paid great attention, especially women who are infected with high-risk HPV.
确定非典型鳞状细胞意义不明确（ASC-US）女性患者宫颈上皮内瘤变组织学诊断的患病率及相关因素。
2007年4月至2008年11月，对北京12个区25 - 54岁的已婚女性进行抽样调查。对细胞学筛查中ASC-US的女性进行进一步检查和分析。
6339名女性中，9.6%存在细胞学宫颈异常；其中409例为ASC-US。409例ASC-US中，42.1%为炎症；50.9%为CIN 1，6.1%为CIN 2，3例为CIN 3，其中1例为宫颈癌。404例进行了人乳头瘤病毒（HPV）检测，感染率为30.7%。HPV感染患者中CIN 2及以上的发病率显著高于未感染人群（χ2 = 26.685，p = 0.000）。ASC-US的病理结果与HPV感染载量之间的相关性无统计学意义（χ2 = 7.754，p = 0.458）。
北京ASC-US女性患者中CIN的发病率较高，应高度重视ASC-US女性，尤其是感染高危HPV的女性。
