Simões M, Cunha V, Nabais H, Riscado I, Jorge A F
Maternidade Dr. Alfredo da Costa, Lisboa, Portugal.
Eur J Gynaecol Oncol. 2011;32(4):448-51.
Malignant melanoma (MM) represents 1% of all cancers and has an incidence of 3-7% in the female genital tract, the majority of cases being reported in the vulva and vagina.
A 75-year-old white female had a history of vaginal bleeding due to a 1.5 cm exophytic and ulcerated cervical lesion. Incisional biopsy was taken and sent for histopathological examination, which revealed MM of the cervix, confirmed by immunohistochemistry. Exclusion of the primitive tumor in other sites was made and after FIGO staging (IB1) the patient underwent a radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. Three months later, hepatic and osseous metastases were detected, and the patient underwent chemotherapy and palliative radiotherapy with no success.
Primary MM of the cervix should be considered in the differential diagnosis of cervical malignancies. Early diagnosis is essential in order to warrant a better prognosis, although there are no cases of cure described.
恶性黑色素瘤（MM）占所有癌症的1%，在女性生殖道中的发病率为3%-7%，大多数病例报告发生在外阴和阴道。
一名75岁的白人女性有因宫颈1.5厘米外生性溃疡病变导致阴道出血的病史。进行了切口活检并送去做组织病理学检查，结果显示为宫颈MM，免疫组化予以证实。排除了其他部位的原发性肿瘤，在国际妇产科联盟（FIGO）分期（IB1）后，患者接受了根治性子宫切除术、双侧输卵管卵巢切除术和盆腔淋巴结清扫术。三个月后，检测到肝转移和骨转移，患者接受了化疗和姑息性放疗，但未成功。
在宫颈恶性肿瘤的鉴别诊断中应考虑原发性宫颈MM。早期诊断对于获得更好的预后至关重要，尽管尚无治愈病例的描述。
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