Ferrieri P
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis 55455.
Rev Infect Dis. 1990 May-Jun;12 Suppl 4:S394-400. doi: 10.1093/clinids/12.supplement_4.s394.
Neonatal bacterial sepsis has continued in this decade to contribute significantly to neonatal mortality and morbidity and is a critical determinant of outcome in infants of very low birth weight despite the availability of antibiotics. The group B Streptococcus and Escherichia coli are the predominant pathogens for the newborn infant. Studies on the epidemiology, microbiology, and immunology of group B streptococcal disease are more extensive than those on E. coli disease. Type-specific antibodies, polymorphonuclear leukocytes, and complement are integral to immunity against group B Streptococcus, and experimental data are presented to support the importance of these components. The newborn infant is handicapped by temporary deficiencies in host defenses, and approaches for restoring immunocompetence, such as immunization of the mother or passive administration of intravenous immunoglobulins or other immune factors, are presented for consideration. Further studies are required to demonstrate the safety, feasibility, and efficacy of these approaches.
在这十年中，新生儿细菌性败血症仍然是导致新生儿死亡和发病的重要因素，并且是极低出生体重儿预后的关键决定因素，尽管已有抗生素可用。B族链球菌和大肠杆菌是新生儿的主要病原体。关于B族链球菌疾病的流行病学、微生物学和免疫学的研究比大肠杆菌疾病的研究更为广泛。型特异性抗体、多形核白细胞和补体是抗B族链球菌免疫的组成部分，并提供了实验数据以支持这些成分的重要性。新生儿因宿主防御功能暂时不足而受到影响，并提出了恢复免疫能力的方法，如对母亲进行免疫或静脉注射免疫球蛋白或其他免疫因子的被动给药，以供考虑。需要进一步研究来证明这些方法的安全性、可行性和有效性。
