基于荧光咪唑环番的对鸟嘌呤核苷酸-5'-三磷酸和 I(-)在生理 pH 水溶液中的检测。
Fluorescent imidazolium-based cyclophane for detection of guanosine-5'-triphosphate and I(-) in aqueous solution of physiological pH.
机构信息
Center for Superfunctional Materials, Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Korea.
出版信息
Org Lett. 2011 Oct 21;13(20):5476-9. doi: 10.1021/ol202183t. Epub 2011 Sep 26.
A new water-soluble and fluorescent imidazolium-anthracene cyclophane (1) effectively recognizes the biologically important GTP and I(-) over other anions in a 100% aqueous solution of physiological pH 7.4. Fluorescence and (1)H NMR spectra and ab initio calculations demonstrate that emission arises from the formation of an excimer state and quenching occurs upon GTP/I(-) binding through (C-H)(+)···A(-) hydrogen bond interactions.
一种新的水溶性和荧光咪唑并蒽环（1）在生理 pH 值为 7.4 的 100%水溶液中能够有效地识别出生物上重要的 GTP 和 I(-)，而不是其他阴离子。荧光和（1）H NMR 光谱以及从头算计算表明，发射源于形成激基态，而通过（C-H)(+)···A(-)氢键相互作用与 GTP/I(-)结合会导致猝灭。
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