Grivaux M, Zureik M, Marsal L, Asselain B, Peureux M, Chavaillon J-M, Prudhomme A, Carbonnelle M, Goarant E, Maury B, Bedossa A, Blanchon F
Service de pneumologie, hôpital de Meaux, 6-8, rue Saint-Fiacre, BP 218, 77104 Meaux cedex, France.
Rev Mal Respir. 2011 Sep;28(7):e31-8. doi: 10.1016/j.rmr.2008.07.001. Epub 2011 Aug 2.
In 2000, the college of pulmonologists of general hospitals undertook an epidemiological study (KBP-2000-CPHG) enrolling all new cases of histologically confirmed lung cancer managed in general hospitals. This paper reports the 5-year survival in these cases.
Vital status was available for 5447 out of 5667 patients included in the original study. The effect of different prognostic factors on mortality was assessed.
At 5 years, 567 patients (10.4%) were still alive. Median survival for the 4880 (89.6%) deceased patients was 7 months. Univariate analysis identified age, smoking history, performance status, histological type and disease stage (TMN classification) as determinants of survival. For non-small cell lung cancer (n=4885) multivariate analysis identified five predictive factors for mortality - age, gender, histological type, performance status and stage.
Five-year survival in lung cancer continues to be poor. As the risk factors for poor outcome at the time of diagnosis are not modifiable and pending, the results of screening studies reduction in mortality must rest on primary prevention.
2000年，综合医院的肺科医师学院开展了一项流行病学研究（KBP - 2000 - CPHG），纳入了综合医院所有经组织学确诊的肺癌新病例。本文报告了这些病例的5年生存率。
在最初纳入研究的5667例患者中，有5447例的生命状态信息可用。评估了不同预后因素对死亡率的影响。
5年后，567例患者（10.4%）仍存活。4880例（89.6%）死亡患者的中位生存期为7个月。单因素分析确定年龄、吸烟史、体能状态、组织学类型和疾病分期（TMN分类）为生存的决定因素。对于非小细胞肺癌（n = 4885），多因素分析确定了五个死亡预测因素——年龄、性别、组织学类型、体能状态和分期。
肺癌的5年生存率仍然很低。由于诊断时预后不良的危险因素无法改变且尚无定论，筛查研究降低死亡率只能依靠一级预防。
